Identification of new quantitative trait Loci (other than the PRNP gene) modulating the scrapie incubation period in sheep.
نویسندگان
چکیده
Although susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detected on OAR6 and OAR18.
منابع مشابه
Genotyping of PRNP coding region for scrapie in Indian sheep
Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative disease by an entirely novel mechanism. The conformational change in prion proteins results in a change from a predominantly α-helical protein to a β-sheet form, which causes scrapie in sheep and goat. The present study was carried out to identify polymorphisms of the prion protein gene (PrP) ...
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ورودعنوان ژورنال:
- Genetics
دوره 179 1 شماره
صفحات -
تاریخ انتشار 2008